Escher, Sylvia: search on Z-Library

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1

Integrated in silico models for the prediction of No-Observed-(Adverse)-Effect-Levels and Lowest-Observed-(Adverse)-Effect-Levels in rats for sub-chronic repeated dose toxicity

Gadaleta, Domenico, Marzo, Marco, Toropov, Andrey Andreevich, Toropova, Alla, Lavado, Giovanna Janet, Escher, Sylvia, Dorne, Jean-Lou, Benfenati, Emilio

Journal:

Chemical Research in Toxicology

Year:

2020

File:

PDF, 573 KB

2020

2

Refinement of TTC values: Identification of outliers in Cramer class 1–3

Inga Tluczkiewicz, Sylvia Escher, Annette Bitsch, Inge Mangelsdorf

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 76 KB

english, 2009

3

Fmoc-based synthesis of the human CC chemokine CCL14/HCC-1 by SPPS and native chemical ligation

Sylvia E. Escher, Enno Klüver, Knut Adermann

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2001

Language:

english

File:

PDF, 276 KB

english, 2001

4

Toxicological categories—A necessary extension of the chemical category approach

Sara Weiss, Sylvia Escher, Annette Bitsch, Inge Mangelsdorf

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 76 KB

english, 2009

5

Influence of study parameters on TTC

Sylvia Escher, Annette Bitsch, Monika Batke, Christine Melber, Nelly Simetska, Inge Mangelsdorf

Journal:

Toxicology Letters

Year:

2008

Language:

english

File:

PDF, 72 KB

english, 2008

6

Route to route extrapolation factors for regulatory risk assessment—A probabilistic approach

Schroeder, Katrin, Hoffmann-Doerr, Simone, Mangelsdorf, Inge, Escher, Sylvia

Journal:

Toxicology Letters

Year:

2014

Language:

english

File:

PDF, 85 KB

english, 2014

7

“Watching the Detectives” report of the general assembly of the EU project DETECTIVE Brussels, 24–25 November 2015

Fernando, Ruani N., Chaudhari, Umesh, Escher, Sylvia E., Hengstler, Jan G., Hescheler, Jürgen, Jennings, Paul, Keun, Hector C., Kleinjans, Jos C. S., Kolde, Raivo, Kollipara, Laxmikanth, Kopp-Schneide

Journal:

Archives of Toxicology

Year:

2016

Language:

english

File:

PDF, 743 KB

english, 2016

8

Breath—A database on occupational exposure limits and local irritation

Monika Batke, Sylvia Escher, Annette Bitsch, Christine Melber, Nelly Simetska, Katarzyna Konieczko, Slawomir Czerczak, Inge Mangelsdorf

Journal:

Toxicology Letters

Year:

2008

Language:

english

File:

PDF, 71 KB

english, 2008

9

How valid are “old” repeated dose toxicity studies for chemical risk assessment?

Monika Batke, Sylvia Escher, Annette Bitsch, Christine Melber, Nelly Simetska, Inge Mangelsdorf

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 93 KB

english, 2009

10

RepDose and FeDTex: Two databases focusing on systemic toxicity: First examples from analyses of repeated dose toxicity and reprotoxicity studies

Annette Bitsch, Sylvia Escher, Geertje Lewin, Christine Melber, Nelly Simetska, Inge Mangelsdorf

Journal:

Toxicology Letters

Year:

2008

Language:

english

File:

PDF, 76 KB

english, 2008

11

Read-across of 90-day rat oral repeated-dose toxicity: A case study for selected n -alkanols

Schultz, Terry W., Przybylak, Katarzyna R., Richarz, Andrea-Nicole, Mellor, Claire L., Escher, Sylvia E., Bradbury, Steven P., Cronin, Mark T.D.

Journal:

Computational Toxicology

Year:

2017

Language:

english

File:

PDF, 410 KB

english, 2017

12

The OSIRIS Weight of Evidence approach: ITS mutagenicity and ITS carcinogenicity

Buist, Harrie, Aldenberg, Tom, Batke, Monika, Escher, Sylvia, Klein Entink, Rinke, Kühne, Ralph, Marquart, Hans, Pauné, Eduard, Rorije, Emiel, Schüürmann, Gerrit, Kroese, Dinant

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 1007 KB

english, 2013

13

Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity - The hyperbilirubinemia use case

Kotsampasakou, Eleni, Escher, Sylvia E., Ecker, Gerhard F.

Journal:

European Journal of Pharmaceutical Sciences

Year:

2017

Language:

english

File:

PDF, 868 KB

english, 2017

14

OpenTox predictive toxicology framework: toxicological ontology and semantic media wiki-based OpenToxipedia

Olga Tcheremenskaia, Romualdo Benigni, Ivelina Nikolova, Nina Jeliazkova, Sylvia E Escher, Monika Batke, Thomas Baier, Vladimir Poroikov, Alexey Lagunin, Micha Rautenberg, Barry Hardy

Journal:

Journal of Biomedical Semantics

Year:

2012

Language:

english

File:

PDF, 727 KB

english, 2012

15

Corrigendum to “The application of new HARD-descriptor available from the CORAL software to building up NOAEL models” [Food Chem. Toxicol. 112 (2018) 544–550]

Toropova, Alla P., Toropov, Andrey A., Marzo, Marco, Escher, Sylvia E., Dorne, Jean Lou, Georgiadis, Nikolaos, Benfenati, Emilio

Journal:

Food and Chemical Toxicology

Year:

2019

Language:

english

File:

PDF, 120 KB

english, 2019

16

OSIRIS, a quest for proof of principle for integrated testing strategies of chemicals for four human health endpoints

Vermeire, Theo, Aldenberg, Tom, Buist, Harrie, Escher, Sylvia, Mangelsdorf, Inge, Pauné, Eduard, Rorije, Emiel, Kroese, Dinant

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 825 KB

english, 2013

17

Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project

Escher, Sylvia E., Kamp, Hennicke, Bennekou, Susanne H., Bitsch, Annette, Fisher, Ciarán, Graepel, Rabea, Hengstler, Jan G., Herzler, Matthias, Knight, Derek, Leist, Marcel, Norinder, Ulf, Ouédraogo,

Journal:

Archives of Toxicology

Year:

2019

File:

PDF, 2.36 MB

2019

18

Subject index volume 85

Vermeire, Theo, Aldenberg, Tom, Buist, Harrie, Escher, Sylvia, Mangelsdorf, Inge, Pauné, Eduard, Rorije, Emiel, Kroese, Dinant

Journal:

Year:

1994

Language:

english

File:

PDF, 347 KB

english, 1994

19

How valid are old repeated dose toxicity studies for chemical risk assessment?

Inge Mangelsdorf, Monika Batke, Sylvia Escher

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 45 KB

english, 2009

20

Inhalation threshold of toxicological concern (TTC) — Structural alerts discriminate high from low repeated-dose inhalation toxicity

Schüürmann, Gerrit, Ebert, Ralf-Uwe, Tluczkiewicz, Inga, Escher, Sylvia E., Kühne, Ralph

Journal:

Environment International

Year:

2016

Language:

english

File:

PDF, 1.79 MB

english, 2016

21

PI3Kγ deficiency delays the onset of experimental autoimmune encephalomyelitis and ameliorates its clinical outcome

Luciana Berod, Christina Heinemann, Sylvia Heink, Angelika Escher, Christine Stadelmann, Sebastian Drube, Reinhard Wetzker, Johannes Norgauer, Thomas Kamradt

Journal:

European Journal of Immunology

Year:

2011

Language:

english

File:

PDF, 560 KB

english, 2011

22

Read-across of 90-day rat oral repeated-dose toxicity: A case study for selected β-olefinic alcohols

Przybylak, Katarzyna R., Schultz, Terry W., Richarz, Andrea-N., Mellor, Claire L., Escher, Sylvia E., Cronin, Mark T.D.

Journal:

Computational Toxicology

Year:

2017

Language:

english

File:

PDF, 643 KB

english, 2017

23

Final Report: Applying a tested procedure for the identification of potential emerging chemical risks in the food chain to the substances registered under REACH ‐ REACH 2

Oltmanns, Jan, Bohlen, Marie‐Léonie, Escher, Sylvia, Schwarz, Markus, Licht, Oliver

Journal:

EFSA Supporting Publications

Year:

2019

Language:

english

File:

PDF, 6.08 MB

english, 2019

24

Final report: Testing a procedure for the identification of emerging chemical risks in the food chain. External Scientific Report. OC/EFSA/SCER/2014/03

Bitsch, Annette, Bohlen, Marie‐Léonie, Escher, Sylvia, Licht, Oliver, Oltmanns, Jan, Schneider, Klaus, Wibbertmann, Axel

Journal:

EFSA Supporting Publications

Year:

2016

Language:

english

File:

PDF, 10.12 MB

english, 2016

25

Atenção Farmacêutica em Goiânia: inserção do farmacêutico na Estratégia Saúde da Família

Provin, Mércia Pandolfo, Campos, Andréa de Paula, Nielson, Sylvia Escher de Oliveira, Amaral, Rita Goreti

Journal:

Saúde e Sociedade

Year:

2010

File:

PDF, 250 KB

2010

26

Comparing in vitro human liver models to in vivo human liver using RNA-Seq

Gupta, Rajinder, Schrooders, Yannick, Hauser, Duncan, van Herwijnen, Marcel, Albrecht, Wiebke, ter Braak, Bas, Brecklinghaus, Tim, Castell, Jose V., Elenschneider, Leroy, Escher, Sylvia, Guye, Patrick

Journal:

Archives of Toxicology

Year:

2020

File:

PDF, 6.81 MB

2020

27

Increase of expression and activation of chemokine CCL15 in chronic renal failure

Rudolf Richter, Ulf Forssmann, Reinhard Henschler, Sylvia Escher, Adjoa Frimpong-Boateng, Wolf-Georg Forssmann

Journal:

Biochemical and Biophysical Research Communications

Year:

2006

Language:

english

File:

PDF, 243 KB

english, 2006

28

Evaluation of the TTC concept with the database RepDose

Sylvia Escher, Inge Mangelsdorf

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 45 KB

english, 2009

29

The OSIRIS Weight of Evidence approach: ITS for the endpoints repeated-dose toxicity (RepDose ITS)

Tluczkiewicz, Inga, Batke, Monika, Kroese, Dinant, Buist, Harrie, Aldenberg, Tom, Pauné, Eduard, Grimm, Helvi, Kühne, Ralph, Schüürmann, Gerrit, Mangelsdorf, Inge, Escher, Sylvia E.

Journal:

Regulatory Toxicology and Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.63 MB

english, 2013

30

Fmoc-based synthesis of the human CC chemokine CCL14/HCC-1 by SPPS and native chemical ligation

Sylvia E. Escher, Enno Klüver, Knut Adermann

Journal:

International Journal of Peptide Research and Therapeutics

Year:

2001

Language:

english

File:

PDF, 711 KB

english, 2001

31

The application of new HARD-descriptor available from the CORAL software to building up NOAEL models

Toropova, Alla P., Toropov, Andrey A., Marzo, Marco, Escher, Sylvia E., Dorne, Jean Lou, Georgiadis, Nikolaos, Benfenati, Emilio

Journal:

Food and Chemical Toxicology

Year:

2017

Language:

english

File:

PDF, 828 KB

english, 2017

32

Evaluation of risk assessment factors for inter-species and time-extrapolation

Sylvia Escher, Inge Mangelsdorf

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 105 KB

english, 2009

33

Curated human hyperbilirubinemia data and the respective OATP1B1 and 1B3 inhibition predictions

Kotsampasakou, Eleni, Escher, Sylvia E., Ecker, Gerhard F.

Journal:

Year:

2017

Language:

english

File:

PDF, 145 KB

english, 2017

34

Exposure-based waiving under REACH

Theo Vermeire, Marja van de Bovenkamp, Yuri Bruinen de Bruin, Christiaan Delmaar, Jacqueline van Engelen, Sylvia Escher, Hans Marquart, Tim Meijster

Journal:

Regulatory Toxicology and Pharmacology

Year:

2010

Language:

english

File:

PDF, 682 KB

english, 2010

35

Applicability domain of TTC (Threshold of Toxicological Concern) schemes—A conceptual approach

Gerrit Schüürmann, Ralf-Uwe Ebert, Sylvia Escher, Inge Mangelsdorf, Ralph Kühne

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 46 KB

english, 2009

36

Sound oral to inhalation extrapolation factors for human health risk assessment

Sylvia Escher, Inge Mangelsdorf

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 91 KB

english, 2009

37

Combining In Vivo Data with In Silico Predictions for Modeling Hepatic Steatosis by Using Stratified Bagging and Conformal Prediction

Jain, Sankalp, Norinder, Ulf, Escher, Sylvia E., Zdrazil, Barbara

Journal:

Chemical Research in Toxicology

Year:

2020

File:

PDF, 2.77 MB

2020

38

Solution Structure of the Human CC Chemokine 2: A Monomeric Representative of the CC Chemokine Subtype †,‡

Sticht, Heinrich, Escher, Sylvia E., Schweimer, Kristian, Forssmann, Wolf-Georg, Rösch, Paul, Adermann, Knut

Journal:

Year:

1999

Language:

english

File:

PDF, 156 KB

english, 1999

39

Interspecies extrapolation based on the RepDose database—A probabilistic approach

Escher, Sylvia E., Batke, Monika, Hoffmann-Doerr, Simone, Messinger, Horst, Mangelsdorf, Inge

Journal:

Toxicology Letters

Year:

2013

Language:

english

File:

PDF, 266 KB

english, 2013

40

TTC: A new concept for inhalation exposure

Escher, Sylvia, Tluczkiewicz, Inga, Kühne, Ralph, Ebert, Ralf-Uwe, Schüürmann, Gerrit, Mangelsdorf, Inge

Journal:

Toxicology Letters

Year:

2013

Language:

english

File:

PDF, 77 KB

english, 2013

41

Structural features of endocrine active chemicals – A comparison of in vivo and in vitro data

Lewin, Geertje, Escher, Sylvia E., van der Burg, Bart, Simetska, Nelly, Mangelsdorf, Inge

Journal:

Reproductive Toxicology

Year:

2015

Language:

english

File:

PDF, 2.20 MB

english, 2015

42

Extension of the carcinogen dose–response database for threshold of toxicological concern

Cronin, Mark, Belfield, Samuel, Escher, Sylvia, Firman, James, Lieu, Jie, Marsaux, Cyril, Mostrag-Szlichtyng, Aleksandra, Przybylak, Katarzyna, Rathman, James, Tarkhov, Aleksey, Yang, Chihae

Journal:

Toxicology Letters

Year:

2017

Language:

english

File:

PDF, 57 KB

english, 2017

43

Towards grouping concepts based on new approach methodologies in chemical hazard assessment: the read-across approach of the EU-ToxRisk project

Escher, Sylvia E., Kamp, Hennicke, Bennekou, Susanne H., Bitsch, Annette, Fisher, Ciarán, Graepel, Rabea, Hengstler, Jan G., Herzler, Matthias, Knight, Derek, Leist, Marcel, Norinder, Ulf, Ouédraogo,

Journal:

Archives of Toxicology

Year:

2019

Language:

english

File:

PDF, 2.36 MB

english, 2019

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